Nat Biotechnol·· 6 hours agoPickScore72
Recordanelles capture transient gene expression in single human cells.
In brief
Recordanelles are synthetic organelles that can record RNA in single human cells over several days and be read with single-cell sensitivity. The work by Reinkemeier et al., published in Nature Biotechnology (DOI: https://doi.org/10.1038/s41587-026-03327-6), addresses the problem that RNA sequencing cannot capture transient transcriptional changes at transcriptome-wide scale over long periods.
Why it matters
It provides a single-cell way to record transient RNA events over days, where RNA sequencing yields only instantaneous transcriptome snapshots.
Source: Nat Biotechnol · doi.org