Cell· Hannah N. Bell, Kavya Nair, Kole Tison, Peng Liao, Hongwei Lei, Marwa O. El-Derany, Ayijiang Yisimayi, Haiwei Zhang, Ryan Rebernick, Weichao Wang, Yoshitaka Adachi, Cristina Castillo, Nupur K. Das, Jinsu An, Vivien R. Sutton, Xun Lin, Heng Lin, Xinghao Wang, Yunfei Li, Linda Vatan, Amr Aboud, Shuang Wei, Miguel Gijon, Samantha Goodwin, Yatrik M. Shah, Ilona Kryczek, Joseph A. Trapani, Margarida Barroso, Judy Lieberman, Weiping Zou·· 19 hours agoPickScore78
Perforin triggers iron-induced mitochondrial damage to drive ferroptosis and anti-tumor immunity
In brief
Perforin can trigger ferroptosis by promoting iron uptake and mitochondrial iron overload, forming a tumor cell killing mechanism independent of granzymes. This pathway links cytotoxic immunity to iron metabolism and predicts patient response to immune checkpoint blockade. The authors suggest iron supplementation may be a way to enhance anti-tumor immunity.
Why it matters
The paper identifies a granzyme-independent perforin killing pathway, connecting iron uptake, mitochondrial iron overload and ferroptosis.
Source: Cell · cell.com