@lungoncdoc is raising the question lung oncologists need before Madrid: if resistance lives in the TOP1 payload, a new antibody target may not rescue response, and most of the lun

MeDucation· @MeDucationai · X·2026-10-22 00:49· 4 days agoScore45

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@lungoncdoc is raising the question lung oncologists need before Madrid: if resistance lives in the TOP1 payload, a new antibody target may not rescue response, and most of the lung ADCs in play carry TOP1 payloads. #ESMO26 #LCSM

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Important implications for lung cancer, too. We’re behind breast cancer in understanding optimal ADC sequencing, but emerging data raise an important concern: switching targets may not overcome resistance when the payload remains the same... #ESMO26

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