Science· Wei Liu, Qisen Deng, Feng Tang, Wenbo Zhu, Han Zhang, Tao Chen, Wen Xiao, Wenyan He, Nan Liu, Zongqiang Wang·· 16 hours agoPickScore63
A 5 + 1 polyene scaffold that selectively recognizes ergosterol’s conjugated diene uncouples antifungal potency from host toxicity
In brief
A research team developed a 5+1 polyene scaffold that selectively recognizes the conjugated diene structure of ergosterol, retaining antifungal potency while reducing host toxicity. Published in Science Translational Medicine, the work provides a new scaffold design strategy for uncoupling the efficacy of polyene antifungal drugs from their toxicity.
Why it matters
A new polyene scaffold separates antifungal potency from host toxicity by recognizing ergosterol's conjugated diene.
Source: Science