Next-generation ADCs: payload innovation
T-DXd is already rewriting the first-line standard.
MSK experts presented findings from their latest foundational and translational oncology research at #AACR26.
Here's a quick research roundup:
🔬 Highlights included treatment of early-stage #rectalcancer with protein inhibitors targeting HER2, alleviating the need for some patients to receive radiation and/or surgery. cc: @MichaelFoote & @AndreaCercek
🔬 Additional topics included the development of a personalized RNA vaccine for #pancreaticcancer, with almost 90% of responders still alive six years after treatment. cc: @TheVinodLab
🔬 And development of a framework to understand biomarkers and vulnerabilities during the early to late stages of transitions from #lungcancer-enabling adenomas to neuroendocrine lineage plasticity. cc: @jmchan88
Read more about these studies: https://t.co/KSoBfVaGnW
@AACR
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Chia-Ling Wu, Meghana Trivedi, Shivaani Suresh Kanna
Read the abstract →Mailin Li, Xen Ping Hoi, Jenying Deng, Junjun Zheng, Rabia Hashmani, Recep Bayraktar, Wei Qian, Jianying Zhou, Jian Guan, Kai Sun, Hanh Mai, Tiffany Sheu, Susan Haley, Mary Schwartz, Sunil Mathur, Stephen T. Wong, Fotis Nikolo, Keith Syson Chan, Polly Niravath, Jenny C. Chang
Read the abstract →Michael B. Foote, Jinru Shia, Callahan Wilde, Marinela Capanu, Joanne Chou, Vetri Sudar Jayaprakasam, Marc Gollub, Miteshkumar Patel, Mina Ito, Leonard B. Saltz, Devika Rao, Neil Segal, Maliha Nusrat, Karuna Ganesh, Paul Romesser, Julio Garcia-Aguilar, Martin Weiser, Rona Yaeger, Luis A. Diaz, Andrea Cercek
Read the abstract →Vicente Valero, Paula R. Pohlmann, Jason Mouabbi, Xuelin Huang, Wei Qiao, Heather R. Alonzo, Rashmi Krishna Murthy, Gaiane M. Rauch, Taiwo Adesoye, Cristina M. Checka, William F. Symmans, Dmitri Grachev, Flora Alajajyan, Adaeze Nwosu-Iheme, Amy Hassan, Miral Mahesh Patel, Sharon H. Giordano, Kelly Hunt, Debasish Tripathy, Funda Meric-Bernstam
Read the abstract →Elizabeth K. Lee, Andrea Wahner Hendrickson, Gerardo Colon-Otero, Cheryl A. Pickett, Yinglu Zhou, Su-Chun Cheng, Madeline Polak, Hannah Sawyer, Martin Hayes, Ursula A. Matulonis, Geoffrey I. Shapiro, Panagiotis A. Konstantinopoulos
Read the abstract →Steven J Isakoff, Anastasia Martynova, Philippe L Bedard, Margaret E Gatti-Mays, Nathalie LeVasseur, Andreas Varkaris, William Randolph, Karunya Srinivasan, Shannon McCue, Zhenming Shun, Ke Liu, Zhen Su, Kevin Chin, Virginia Kaklamani, Kelly McCann, Erika Hamilton
Read the abstract →Source: x.com · x.com