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Wafik S. El-Deiry, MD, PhD, FACP· @weldeiry · X·· 2026-04-21Score60

MEK

Reading

KRAS / RAS targeting: from platform to Phase 3

Body

Visiting with #eldeirylab member and
@BrownUniversity
alum Connor Purcell as he presents on “Combination of CDK4/6 inhibitory and anti-hypoxia miRNA-6883 lipid nanoparticles with ferroptosis inducers or MEK inhibitors in preclinical breast and colorectal cancer models” at #AACR26

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Conference abstracts
CT129matched by 代号 NST-628
Preliminary results from a Phase 1a/b dose-escalation and expansion trial of the pan-RAF-MEK molecular glue NST-628 in patients (pts) with advanced or refractory RAF, KRAS, and NRAS-mutant solid tumors

Ahmad A. Tarhini, Monica Chen, Jia Liu, Varun Monga, Victoria Atkinson, Sarina A. Piha-Paul, Bartosz Chmielowski, Benjamin Herzberg, Charlotte Lemech, Prachi Bhave, Ganessan Kichenadasse, Gerald Falchook, Janice Mehnert, Andrae Vandross, Mohamad Salkeni, Meredith McKean, David Wages, Ann Marie Kennedy, Meagan B. Ryan, John Clark, Abdulaziz Nanah, Michael J. Fossler, Philip Komarnitsky, Igor Puzanov

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Source: Wafik S. El-Deiry, MD, PhD, FACP · x.com

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