Nature· Florence Magrangeas·· 15 hours agoPickScore57
Molecular predictors of minimal residual disease in newly diagnosed multiple myeloma treated with quadruplet therapy
In brief
A multiomic analysis of patients with newly diagnosed multiple myeloma treated with isatuximab, carfilzomib, lenalidomide and dexamethasone induction, followed by MRD-status-guided consolidation, found that baseline genomic, transcriptomic and epigenetic features were associated with post-induction MRD status. doi: 10.1038/s41591-026-04692-0.
Why it matters
Links baseline genomic, transcriptomic and epigenetic features to post-induction MRD status under IsaKRd quadruplet induction, informing future MRD-guided consolidation studies.
Source: Nature