cell.com· Luke D. Lynch, Jinho Park, Gheorghe Chistol·· 19 hours agoPickScore69
Metazoan lagging-strand DNA synthesis is distributive
In brief
Single-molecule imaging shows that metazoan lagging-strand DNA synthesis is distributive, driven by repeated recruitment of Pol α and Pol δ rather than stable association of both with the replisome. This mechanism uncouples leading- and lagging-strand synthesis, distinguishing it from the conventional replication fork model in which the two act together. Link: https://www.cell.com/cell/fulltext/S0092-8674(26)01204-3?rss=yes
Why it matters
Single-molecule imaging shows lagging-strand synthesis relies on repeated Pol α and Pol δ recruitment, not stable binding.
Source: cell.com · cell.com