MRD / ctDNA / DTP: from detection to treatment decisions
Nivolumab, pembrolizumab and durvalumab sit in this direction not as new drugs, but because perioperative IO trials wrote ctDNA into the stratification.
🎉 Exciting #AACR26 highlights!
Featured: NEOPRISM-CRC Trial - Dr. Jiang (@uclcancer) presented NeXT Personal® results in high-risk stage II-III dMMR/MSI-H colorectal cancer with neoadjuvant pembrolizumab.
✅ 100% of super molecular responders achieved pCR.
✅ 100% of poor responders did NOT achieve pCR.
✅ 100% NPV & specificity for disease relapse, post-surgery.
Study identified 3 distinct patient response groups to neoadjuvant treatment. 🎯
Other key highlights:
💪 10K patient real-world data: median LOD of 1.92 PPM.
💪 NEW Real-Time Variant Tracker™ feature for resistance monitoring.
💪 DARWIN 2: NeXT Personal risk stratified patients with NSCLC receiving immunotherapy.
Full details: https://t.co/IoHnOpviqk.
(Not affiliated with or endorsed by AACR)
#PrecisionOncology #MRD #ctDNA #ClinicalTrials #CancerResearch #TherapyDevelopment #ColorectalCancer #NSCLC #LungCancer #ImmunoTherapy #NeoadjuvantTherapy
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