bioRxiv Genomics· Spin, J. M., Mulorz, J. U., Shen, W.-J., Amirahmadi, M., Rhee, Y. H., Deng, A., Chavan, S., Butterfield, J., Mulorz, P., Wagenhauser, M. U., Headley, C., Qiu, T., Tsao, P. S. ·· 15 hours agoPickScore61
Maternal E-cigarette Exposure Augments Murine Abdominal Aortic Aneurysm
In brief
Maternal e-cigarette nicotine exposure increased offspring AAA growth in two mouse models and raised AAA incidence in ApoE-/- males. Pregnant ApoE-/- and C57BL/6J females were exposed to e-cigarette vapor during gestation; AAAs were induced in adult offspring with elastase or angiotensin II and tracked by ultrasound for 4 weeks. Effects were overall stronger in males.
Why it matters
Complementary results across two mouse models and both sexes, linking AAA growth to RRBS and ATAC-seq epigenetic changes.
Source: bioRxiv Genomics · biorxiv.org