🚨 Major KRAS G12C NSCLC results at #ESMO26!
Phase III Krascendo 1 (N=338): divarasib vs sotorasib/adagrasib.
OS: 17.7 vs 12.0 mo
HR 0.56 (95% CI 0.41–0.78)
PFS: 9.8 vs 5.7 mo
HR 0.58 (0.44–0.76)
An important randomized survival advance. #LCSM
More from Krascendo 1:
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Krascendo 3: A randomised, phase III trial in progress of divarasib vs immunotherapy or observation in patients with resected, stage II-IIIB, KRAS G12C+ non-small cell lung cancer
https://esmocongress.esmo.org- gilberto lopes@GlopesMd
Next: CNS efficacy, resistance, sequencing and moving KRAS inhibition earlier. Skoulidis et al. NEJM 2026.
- gilberto lopes@GlopesMd
ORR: 58.4% vs 32.3% DOR: 11.9 vs 6.9 mo Serious TRAEs: 7.8% vs 15.2% TRAEs leading to discontinuation: 4.8% vs 11.7% Caveats: few adagrasib-treated patients, untreated brain metastases excluded, limited follow-up. Divarasib remains investigational.
Source: gilberto lopes · x.com