Cancer Cell· Fabio Conforti, Valentina Nekljudova, Johannes Holtschmidt, Isabella Sala, Eleonora Pagan, Christine Solbach, Michael Untch, Carsten Denkert, Vincenzo Bagnardi, Marzia Bendoni, Peter A. Fasching, Andreas Schneeweiss, Hans-Joachim Lück, Carmine Valenza, Giuseppe Viale, Tommaso De Pas, Marion van Mackelenbergh, Jens Huober, Volkmar Müller, Theresa Link, Thomas Karn, Mattea Reinisch, Frederik Marmé, Vesna Bjelic-Radisic, Christian Schem, Andreas Hartkopf, Elmar Stickeler, Claus Hanusch, Jens-Uwe Blohmer, Tanja Fehm, Kerstin Rhiem, Richard D. Gelber, Sibylle Loibl·· 21 hours agoScore65
CPS + EG and Neo-Bioscore predict individual outcomes but not trial results after neoadjuvant therapy for early breast cancer
In brief
An analysis of 8,359 patients across nine randomized trials shows that CPS + EG and Neo-Bioscore predict individual outcomes after neoadjuvant chemotherapy but do not reliably predict long-term treatment effects. The study highlights the clinical value of the two scores for individual outcome prediction and their limitations in predicting treatment effects at the trial level.
Source: Cancer Cell · cell.com