Sarah Premji, MD· @SPremji7866 · X·· 2026-04-20Score60
Reading
Next-generation ADCs: payload innovation
T-DXd is already rewriting the first-line standard.
Body
Dr. Elizabeth Lee reviews gapped schedule olaparib plus DS-8201a (T-DXd) in HER2 expressing tumors, endometrial and ovarian cancers, ORR 54%, mDOR 11.2 months, with durable disease control, sound rationale supporting synergism in a gapped schedule based on mechanism #AACR26
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Conference abstracts
Elizabeth K. Lee, Andrea Wahner Hendrickson, Gerardo Colon-Otero, Cheryl A. Pickett, Yinglu Zhou, Su-Chun Cheng, Madeline Polak, Hannah Sawyer, Martin Hayes, Ursula A. Matulonis, Geoffrey I. Shapiro, Panagiotis A. Konstantinopoulos
Read the abstract →Source: Sarah Premji, MD · x.com