Tomosynthesis detects breast cancer more frequently during screening

The TOSYMA randomized trial showed that digital breast tomosynthesis combined with synthetic 2D mammography detected more invasive breast cancers than digital mammography, at 7.1 per 1,000 versus 4.8 per 1,000. In the TOSYMA-2 analysis, the two-year rate of invasive interval cancers was 14.2 per 10,000 versus 18.6 per 10,000, 24% lower but not statistically significant; the first-year rate was 29% lower, and screening program sensitivity was 83.5% versus 72.3%.