Updated POTOMAC data at #ESMO26 in BCG-naïve high-risk NMIBC from Maria De Santos:
Adding durvalumab to BCG improved DFS (HR 0.68), with encouraging results in T1 disease (HR 0.48) and cystectomy-free survival (HR 0.45).
Key question: Is the incremental benefit worth the added toxicity and treatment burden? #ESMO2026 @OncoAlert
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Durvalumab (D) in Combination With BCG Induction and Maintenance (I+M) for BCG-Naïve, High-Risk Non-Muscle-Invasive Bladder Cancer (NMIBC): Early Recurrence and Cystectomy-Free Survival in Patients (pts) With Papillary Only Tumours From POT
https://esmocongress.esmo.orgRapid oral 1: Genitourinary tumours, renal and urothelial
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https://esmocongress.esmo.orgRapid oral 1: Genitourinary tumours, renal and urothelial
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https://esmocongress.esmo.orgSource: David H Aggen, MD PhD · x.com