bioRxiv Genomics· Chauquet, S., Hivert, V., Weger, B., Gachon, F., Yengo, L., Shah, S., McRae, A. F. ·· 15 hours agoPickScore53
Genetic control and tissue specificity of transcriptomic rhythmicity
In brief
Researchers analyzing 50 tissues in GTEx v10 detected rhythmically expressed genes in 49 of them and identified 167 cd-eQTLs, involving 51 genes across 28 tissues. Most cd-eQTLs altered oscillation amplitude, while others affected acrophase or both; effects on core circadian genes were consistent across tissues, whereas those on clock-regulated genes were largely tissue-specific.
Why it matters
Uses donor inferred phase as a circadian time proxy and a cosinor-based genotype-by-rhythm joint interaction framework to test genetic effects on amplitude and acrophase.
Source: bioRxiv Genomics · biorxiv.org