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cancer_navi· @cancer_navi · X·· 2026-04-21Score60

elisrasib

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KRAS / RAS targeting: from platform to Phase 3

Chinese groups are not short of G12C molecules (elisrasib’s floor numbers are strong).

Body

Breaking news from AACR: Single-agent administration of the KRAS G12C inhibitor elisrasib demonstrated tolerability and promising antitumor activity in a phase 1/2 trial in previously treated KRAS G12C mutation-positive non-small cell #lung cancer. Antitumor effects were also

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Conference abstracts
CT303NCT05410145matched by 药名 cetuximab
Safety and efficacy of Elisrasib (D3S-001), a next generation GDP-bound KRAS G12C inhibitor, as monotherapy or combination therapy with cetuximab in previously treated metastatic CRC and PDAC: Results from a phase 1/2 study

Kanwal Pratap Raghav, Jun Zhang, Myung-Ah Lee, Jingdong Zhang, John Park, Yanqiao Zhang, Susana Rosello Keranen, Byoung Chul Cho, Herbert Ho Fung Loong, Cheng Chen, Huan Li, Shaonan Wang, Yandong Shen, Zifei Fan, Qian Chen, Hui Wang, Jing Zhang, George Zhi Jian Chen, Jayesh Desai, Antoine Hollebecque

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Source: cancer_navi · x.com

CBACBA Frontier Insights (CFI)Chinese Biopharmaceutical Association (CBA)www.cba-usa.org