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Oriol Mirallas MD· @DrMirallas · X·· 2026-04-20Score60

elisrasib

Reading

KRAS / RAS targeting: from platform to Phase 3

Chinese groups are not short of G12C molecules (elisrasib’s floor numbers are strong).

Body

#AACR26
New frontiers in oncology

Elisrasib 2/3L #NSCLC #KRASG12C

@cbcbc1971

ORR 59.5% 2L naive
ORR 32.3% 3L refractari
KRASampl ORR 60%
STK11/KEAP1mut ORR 55 vs 71%

New player #KRASG12C
Going to 1L in comb CT+IO
By
@DocSacher

@OncoAlert

@AACR

Heat 58 · 43 likes · 2 replies · 13 reposts

Conference abstracts
CT303NCT05410145matched by 药名 cetuximab
Safety and efficacy of Elisrasib (D3S-001), a next generation GDP-bound KRAS G12C inhibitor, as monotherapy or combination therapy with cetuximab in previously treated metastatic CRC and PDAC: Results from a phase 1/2 study

Kanwal Pratap Raghav, Jun Zhang, Myung-Ah Lee, Jingdong Zhang, John Park, Yanqiao Zhang, Susana Rosello Keranen, Byoung Chul Cho, Herbert Ho Fung Loong, Cheng Chen, Huan Li, Shaonan Wang, Yandong Shen, Zifei Fan, Qian Chen, Hui Wang, Jing Zhang, George Zhi Jian Chen, Jayesh Desai, Antoine Hollebecque

Read the abstract →

Source: Oriol Mirallas MD · x.com

CBACBA Frontier Insights (CFI)Chinese Biopharmaceutical Association (CBA)www.cba-usa.org