馃殌Day 3 Upper GI oral abstracts summary results #ESMO26 馃煟
1) HRS-4642 (KRAS G12D inhibitor) in combination with GnP 卤 adebrelimab as perioperative therapy in resectable or borderline resectable KRAS G12D-mutant pancreatic cancer, ORR 63% and 87%
2) INCB161734, a novel oral KRAS G12D inhibitor, + GnP or mFFX in advanced pancreatic cancer , ORR 62% and 75%
3) LEAP-012 long-term OS data, pembro lenva TACE vs TACE in HCC , no OS benefit
4) C-CAR031, a GPC3-targeted TGF尾RIIDN armored autologous CAR-T, in advanced HCC, manageable safety profile and ORR 44%
5) maintenance olaparib in DDR gene-mutated advanced BTC adter 1L platinum based ChT, median OS 29.6 mo, 2-yer OS rate 53.6%
6) Subcutaneous envafolimab plus GEMOX vs GEMOX in 1L of advanced BTC provided OS benefit
#cancer #oncology #GI #MedX @OncoAlert
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Source: Erman Akkus 路 x.com