顶刊论文（社媒热度）· Sci Adv·· 14 hours agoPickScore64
Phage-ICE tandems facilitate bacterial adaptation and antimicrobial resistance spread.
In brief
The study characterized cotransferable units formed by phage-ICE accretion in Streptococcus and found a fail-safe pathway that spreads via RecA-dependent homologous recombination when excision is impaired. The team screened 612 phage-ICE tandems across seven phyla and 135 species, including multidrug-resistant pathogens, and these units can cotransfer flanking DNA, altering transcriptional programs and oxidative stress tolerance. DOI: 10.1126/sciadv.aed3416
Why it matters
The paper breaks the coordinated transfer of phages and ICEs into excision, conjugation, and recombination, useful as a mechanistic reference for AMR gene spread across species.
Source: 顶刊论文（社媒热度）