KRAS / RAS targeting: from platform to Phase 3
The floor also showed dual ON/OFF (VS-7375) and RM-055, built for amplification and daraxonrasib-resistant models.
The floor rewrote the question from “how long can G12C monotherapy last” to “who first makes first-line pancreatic cancer a standard.” daraxonrasib’s Phase 3 is still the only RAS-inhibitor overall-survival win.
#AACR26
Daraxonrasib monotherapy, a RAS(ON) multi-selective inhibitor, is also making its mark
In 1L mPDAC: ORR 47–51%
DCR 92–97%
6-month PFS 71%
6-month OS 83%
For a chemotherapy-free approach in pancreatic cancer, these results are highly encouraging
https://
aacrjournals.org/cancerres/arti
cle/86/8_Supplement/LB337/782959/Abstract-LB337-Daraxonrasib-monotherapy-as-first?searchresult=1
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