Cell Study Shows Fetal Pancreatic LGR5+ Stem Cells Achieve Three-Lineage Differentiation via Organoids

A study published in Cell shows that fetal pancreatic LGR5+ stem cells achieve three-lineage differentiation through an organoid model. The paper notes that no model previously existed for long-term in vitro culture of human pancreatic progenitor cells while maintaining pluripotency, and that related research relied mainly on morphological observation and transcriptome analysis.