Molecular Cell· William S. Mallen, Nataliya Zabello, Susan Brenner-Morton, Simone Sidoli, Feng-Xia Liang, Joseph Sall, Jason Yin, Priyanka Mathews, Mengmeng Zhu, Guoan Zhang, Carolyn L. Lee, Ya-Cheng Liao, Anthony W.P. Fitzpatrick·· 18 hours agoPickScore70
Amyloid-mediated RNA uptake by sperm for embryonic delivery
In brief
Amyloid fibrils in seminal plasma can bind RNA, enter sperm, and deliver their RNA cargo to the zygote at fertilization. After entry into the zygote, molecular chaperones release the RNA cargo for translation, explaining how extracellular RNA in seminal plasma influences early embryonic development.
Why it matters
The paper provides a continuous mechanism of amyloid fibrils binding RNA, transport via sperm, and chaperone-mediated release after fertilization, filling the gap of how seminal RNA enters the embryo.
Source: Molecular Cell · cell.com