Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages.
In brief
Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages. Circulating taurine concentrations rise with aging in humans and mice; in aged mice, further taurine supplementation extends health span and reduces mortality from sepsis and inflammasome-mediated inflammation.
Why it matters
Positions taurine efflux as a proximal step in NLRP3 inflammasome activation and reveals a mechanism in which supplementation maintains trans-Golgi network integrity.
