medicalxpress.com· Medical Xpress - Immunology·· 2 days agoPickScore68
Previously unrecognized immune cells may drive harmful blood vessel growth in blinding eye diseases
In brief
A Northwestern Medicine study has identified MoPOMs, a population of immune cells that may drive blood vessel growth in wet AMD and proliferative diabetic retinopathy. Published in the Journal of Clinical Investigation, the team analyzed nearly 100,000 immune cells from human and mouse eye tissues and 173 samples, finding that genes including SPP1, FABP5 and IL7R are expressed in lesion-associated macrophages.
Why it matters
The combination of spatial transcriptomics and cell depletion experiments offers a transferable approach to identifying candidate cells in patient tissue and validating their pathogenic role.
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