Nature Communications study uses metabolic modeling to reveal multilevel host-microbiome metabolic network disruption in inflammatory bowel disease

Using host and microbial metabolic modeling, researchers found concurrent dysregulation across data layers in inflammatory bowel disease, spanning NAD, amino acid, one-carbon and phospholipid metabolism. Host tryptophan catabolism was elevated, depleting circulating tryptophan and impairing NAD biosynthesis. The study further predicted dietary interventions that reshape the microbiome and restore metabolic homeostasis.