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Nieves Martinez Lago MD PhD· @DraMartinezLago · X·· 2 days agoScore70

trastuzumab

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#ESMO26 🧬 KC-WISE | Phase III

👥 246 pts | HER2+ GC/GEJ after trastuzumab
💊 Anbenitamab + CT vs CT

🚀 OS: 19.6 vs 9.6 mo (HR 0.39; p<0.0001)
📈 PFS: 7.1 vs 2.7 mo (IRC)
🎯 ORR: 56% vs 14%

⚠️ G≥3 TEAEs: 74.2% vs 54.5%

💡 Major survival benefit, with increased toxicity.

@OncoAlert

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Conference abstracts
1766ROmatched by Rapid oral 1: Breast cancer, advanced stage

Health-related quality of life from HER2CLIMB-05: A phase 3 study of tucatinib versus placebo in combination with trastuzumab and pertuzumab as 1L maintenance therapy for HER2+ mBC

https://esmocongress.esmo.org
1780Pmatched by HER2+ breast cancer

Safety, social costs and quality of life (QOL) in HER2-positive (HER2+) breast cancer (BC) patients (pts) treated with pertuzumab + trastuzumab fixed-dose combination subcutaneous (PT FDC SC): The PERTURB study

https://esmocongress.esmo.org
1795TIPmatched by HER2+ breast cancer

A global, interventional, open-label trial of trastuzumab deruxtecan (T-DXd)–based therapy in first-line HER2-positive metastatic breast cancer: DESTINY-Breast Guide

https://esmocongress.esmo.org
35Pmatched by Advanced breast cancer, other

Comparative effectiveness of trastuzumab deruxtecan versus sacituzumab govitecan in HER2-negative metastatic breast cancer: A real-world analysis with propensity score matching

https://esmocongress.esmo.org
539ROmatched by Rapid oral: Breast cancer, early stage

Patient-reported outcomes (PROs) from DESTINY-Breast05: Health-related quality of life (HRQoL) with trastuzumab Deruxtecan (T-DXd) versus trastuzumab emtansine (T-DM1) in patients (Pts) with high-risk HER2-positive early breast cancer (eBC)

https://esmocongress.esmo.org
543ROmatched by Rapid oral: Breast cancer, early stage

DESTINY-Breast11: MRI-assessed objective responses during neoadjuvant treatment (NAT) with trastuzumab deruxtecan (T-DXd) followed by paclitaxel + trastuzumab + pertuzumab (THP) vs dose-dense doxorubicin + cyclophosphamide followed by THP (

https://esmocongress.esmo.org

Source: Nieves Martinez Lago MD PhD · x.com

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