Cell· Sydnye L. Shuttleworth, Michael A. Bauer, Dennis W. Province, Jessica L. Kelliher, Nicole E. Scharping, Alexander Monell, Lora J. Rogers, Thomas A. Williams, Grant T. Dawson, Katherine F. Wallis, Duah Alkam, Jacob L. Edmondson, Daniel Fil, Aaron J. Storey, Anna L. Bolding, Rick D. Edmondson, Stephanie D. Byrum, Karen E. Beenken, Samuel G. Mackintosh, Ananda W. Goldrath, Alan J. Tackett, Brian Koss·· 19 hours agoPickScore78
Proteomic atlas of T cell exhaustion defines proteostatic collapse
In brief
Researchers built a multi-omic atlas of human T cell exhaustion and found that dysfunctional T cells undergo broad remodeling of protein turnover and ubiquitin regulation, changes not captured by transcriptomic analysis. The E3 ubiquitin ligase RNF166 regulates T cell persistence and anti-tumor function, pointing to proteostasis as a targetable axis for improving immunotherapy.
Why it matters
Proteomics reveals a proteostatic collapse mechanism of T cell exhaustion missed by transcriptomics and identifies RNF166 as a targetable node for improving immunotherapy.
Source: Cell