Cell· Mengci Li, Junliang Kuang, Tianlu Chen, Keke Ding, Yuanyuan Chen, Fuxin Jiao, Yang Li, Peiyang Luo, Linyu Xia, Huiheng Zhang, Jieyi Wang, Dan Zheng, Mingliang Zhao, Tao Sun, Xiaowen Chao, Yuhuai Guo, Min Zhu, Yimin Sun, Xixi Xia, Kun Ge, Chun Qu, Changliang Yao, Guoxiang Xie, Kejun Zhou, Panayiotis Louca, Cristina Menni, Aihua Zhao, Qihao Guo, Xinjian Wan, Lu Zhang, Guang Ji, Jian Zhou, Cheng Hu, Weiping Jia, Xiaojiao Zheng, Wei Jia·· 18 hours agoPickScore79
A microbiome-bile acid axis mediates protection from chronic liver disease in females
In brief
A study published in Cell shows that isoUDCA, a bile acid enriched in females, is jointly produced by gut bacteria favored by estrogen. Through the SREBP2-STARD4-CYP7B1 signaling pathway it promotes hepatic cholesterol handling and bile acid metabolism, alleviating chronic liver injury. The mechanism links estrogen status, gut microbiome composition, and female protection from liver disease on a single signaling axis.
Why it matters
It explains how isoUDCA acts via SREBP2-STARD4-CYP7B1 to aid cholesterol handling and bile acid metabolism and relieve chronic liver injury, useful as a reference for estrogen, gut microbes, and sex differences in liver disease.
Source: Cell