bioRxiv Cancer Biology· Ran, W., Wu, P., Qiao, Z., Wang, S., Yang, Q., Yan, R., Yan, Z., Zhang, J., He, B., Shao, Y., Wang, Y., Chu, S., Wang, Y., Wang, H. ·· 20 hours agoPickScore66
A polysynaptic hypothalamuspelvic-ganglion circuit regulates prostate tumor growth via WNT3A
In brief
A mouse study shows that the PVN-DMV-MPG polysynaptic circuit regulates prostate tumor growth: PVN activity suppresses tumors while DMV activity promotes them. MPG ablation abolished the DMV-mediated pro-tumor effect. LMD combined with Smart-seq2 showed increased Wnt3a expression in activated MPG neurons innervating the tumor under upstream neural control, and neutralizing WNT3A released by MPG explants suppressed explant-induced cancer cell proliferation.
Why it matters
By comparing the opposing effects of PVN and DMV, with MPG ablation, LMD with Smart-seq2, and WNT3A neutralization, the brief maps a brain-derived pro-tumor mechanism.
Source: bioRxiv Cancer Biology · biorxiv.org