Alan Tan· @alantanmd · X·· 14 hours agoScore70
Body · original
DeLLphi-305 at #ESMO26, presented by Jacob Sands, got a standing ovation. An important advance in very aggressive biology. Tarlatamab + durvalumab vs durvalumab as 1L maintenance in ES-SCLC:
▪️ OS HR 0.42, median 21.1 vs 12.7 mo
▪️ PFS HR 0.34
▪️ ORR 26.4% vs 4.1%
Important to study in NEPC and small cell bladder.
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Conference abstracts
LBA3matched by Presidential Symposium I
Tarlatamab plus durvalumab (durva) vs durva as 1L maintenance (1LM) therapy following durva, platinum, and etoposide (1L durva + EP) in extensive-stage small cell lung cancer (ES-SCLC): Primary analysis of the phase 3 DeLLphi-305 trial
https://esmocongress.esmo.orgSource: Alan Tan · x.com