Cell· Nathchar Naowarojna, Xin Gu, Zijian Pan, Jun Yu, Kaiyin Huang, Yuyang Zeng, Yuheng Xie, Yuan Zhang, Fengxiang Wang, Jingxuan Mao, Yanxiong Yu, Tianshu William Wu, Jinshi Yu, Shi’en Liu, Senhao Xiao, Lijie Bai, Dongqi Li, Zhenkun Wu, Caiyi Wei, Qiu Li, Hongqing Yao, Xiaoxiao Zhang, Yupan Li, Guanglei Xie, Lei Gao, Jinheng Pan, Lijun Wang, Jin Hu, Xuefei Feng, Qin Peng, Shan Feng, Xi Wang, Yuqi Wang, Tao Peng, Yikai Wang, Yilong Zou·· 19 hours agoPickScore75
A bioavailable GPX4 inhibitor for ferroptosis induction in vivo and tumor suppression
In brief
Researchers developed KY0418, a systemically deliverable GPX4 inhibitor that induces ferroptosis in multiple models and suppresses tumors in a context-dependent manner. The paper also links systemic ferroptosis induction to tissue metabolic remodeling and suggests that metastatic spread can be inhibited.
Why it matters
The paper provides a systemically deliverable GPX4 inhibitor with tumor-suppression data, notes context-dependent effects, and offers a tool for ferroptosis and GPX4-targeting studies.
Source: Cell