顶刊论文（社媒热度）· Sci Adv·· 15 hours agoPickScore66
Vitamin D binding protein in ventral CA3 of the hippocampus drives stress-induced depression.
In brief
Researchers found up-regulated expression of vitamin D binding protein (VDBP) in CaMKIIα excitatory neurons of the ventral CA3 region of the hippocampus in mice susceptible to chronic unpredictable mild stress (CUMS), and this up-regulation correlated with the severity of depression-like behaviors.
Why it matters
Localizing VDBP in vCA3 CaMKIIα neurons and elucidating its depression-driving mechanism via the PI3K-Akt-mTOR pathway points to new drug targets for MDD.
Source: 顶刊论文（社媒热度）