reddit.com· r/science · Reddit·· 5 hours agoPickScore71
Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea: retatrutide resulted in significantly greater decreases in OSA than placebo.
In brief
Eli Lilly's unapproved triple-target agonist retatrutide showed significantly greater reductions in OSA AHI versus placebo in two phase 3 studies published in NEJM on 2026-10-22 (DOI 10.1056/NEJMoa2611477). Commenters note that only Zepbound currently carries an OSA indication, and debate whether weight loss alone explains the AHI decrease along with long-term efficacy and safety.
Why it matters
Two phase 3 studies showed retatrutide reduced AHI more than placebo, and commenters asked whether mechanisms beyond weight loss are involved.
Source: reddit.com · reddit.com