#ESMO26 LBA3
🚨 DeLLphi-305: Phase 3 results in ES-SCLC!
Tarlatamab + durvalumab vs durvalumab as 1L maintenance (n=563)
✅ OS: 21.1 vs 12.7 mo (HR 0.42)
✅ PFS: 7.4 vs 1.9 mo (HR 0.34)
✅ ORR: 26.4% vs 4.1%
⚠️ CRS: 49.6% (G≥3: 0.4%)
⚠️ ICANS: 1.1%
Impressive survival benefit! A potential new standard of care.
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Tarlatamab plus durvalumab (durva) vs durva as 1L maintenance (1LM) therapy following durva, platinum, and etoposide (1L durva + EP) in extensive-stage small cell lung cancer (ES-SCLC): Primary analysis of the phase 3 DeLLphi-305 trial
https://esmocongress.esmo.org1/4 🔥 #ESMO26 Lung Cancer Presidential Highlights 🇪🇸 Madrid | October 24–25, 2026 Three major Phase 3 lung cancer LBAs, each with potential to reshape treatment paradigms: 🎙️ LBA3 | DeLLphi-305 🎙️ LBA5 | KRASCENDO 1 🎙️ LBA6 | SAFFRON Three Phase 3 readouts to watch closely at #ESMO26 👀 @myESMO @OncoAlert @Larvol在 X 查看被引用的帖子
- Mustafa Özdoğan, MD@ozdogan_md
@M_Torasawa Clear numbers. One frame I'll watch at PS I: OS gain (HR 0.42; +8.4 mo median) vs CRS burden (49.6%, G≥3 rare). Was ICANS systematically captured in both arms?
Source: Masahiro TORASAWA, MD. PhD. · x.com