bioRxiv Cancer Biology· Yang, Q., Yan, J., Zhao, P., Tang, Q., Zheng, K., Zhao, J., Zhou, Z., Yang, Q. ·· 1 day agoScore69
ANO6 Scaffolds ER Mitochondria Contacts to Govern Spatial Lipid Compartmentalization and Ferroptosis Evasion in Chemoresistant Breast Cancer
In brief
The study shows that ANO6 is upregulated in chemotherapy-resistant breast cancer lesions. Through the VIM-ANO6-VAPB-PTPIP51 scaffold at ER-mitochondria contact sites, ANO6 sequesters peroxidizable lipids and thereby evades ferroptosis.
Source: bioRxiv Cancer Biology · biorxiv.org