bioRxiv Cancer Biology· Garcia-Vioque, V., Garcia-Alvarez, A., Moreno-Montilla, M. T., Hernando, J., Blazquez-Encinas, R., Garcia, A., Lopez-Lopez, C., Jimenez-Fonseca, P., Garcia-Carbonero, R., Landolfi, S., Blanco, L., Casteras, A., Vivancos, A., Ibanez-Costa, A., Pedraza-Arevalo, S., Capdevila, J., Castano, J. P. ·· 17 hours agoPickScore50
From Splicing to Survival: Understanding the Molecular Basis of Prognostic Differences in advanced Small Intestine Neuroendocrine Tumors
In brief
A study of advanced small intestine neuroendocrine tumors (SI-NETs) found distinct splicing event patterns between short-survival (<5 years, n=17) and long-survival (>=5 years, n=26) groups. Expression of core spliceosome components and splicing factors differed markedly between groups; high CPSF2 expression was associated with worse survival, vascular invasion, and perineural invasion. CPSF2-related changes may contribute to tumor plasticity, pointing toward greater aggressiveness and treatment resistance, and suggest candidate biomarkers or therapeutic targets.
Why it matters
Splicing patterns and CPSF2 expression distinguish survival groups in advanced SI-NETs.
Source: bioRxiv Cancer Biology · biorxiv.org