Moving beyond #ALK TKIs - a first-in-class ALK molecular glue degrader that could change the game in ALK+ #NSCLC #AACR26.

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LUNGevity Foundation· @LUNGevity · X·2026-04-20 09:36· 2026-04-20Score60

TRI-611

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Medicinal chemistry beyond KRAS: CDK2, WEE1, SERD

TRI-611 · An early code on the floor

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Moving beyond #ALK TKIs - a first-in-class ALK molecular glue degrader that could change the game in ALK+ #NSCLC #AACR26.
Why a degrader instead of another TKI? Acquired resistance is inevitable. TRI-611 works differently -> recruits CRBN to degrade ALK protein entirely,

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Conference abstracts

4618matched by 代号 TRI-611

TRI-611, a development stage molecular glue degrader of ALK for the treatment of ALK-positive NSCLC including central nervous system metastases

Andrew R. Conery, Daniel S. La, Artyom A. Alekseyenko, David Marcoux, Aaron G. Bart, Matt L. Harlow, Patrick R. Arsenault, Nico R. Cantone, Rebecca L. Casaubon, Hari B. Kamadurai, Aravind Prasad Medikonda, Duncan E. Nunes, Tim J. Wigle, Maolin Yu, Aleksandra Zagulyaeva, Christine Zarate, Kathleen I. Seyb, Patrick Trojer, Vito J. Palombella

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5787matched by 代号 TRI-611

TRI-611, a development stage molecular glue degrader of ALK, promotes the degradation of TKI-resistant ALK fusion proteins and leads to regression of ALK TKI-refractory tumors

Andrew R. Conery, Daniel S. La, Artyom A. Alekseyenko, David Marcoux, Aaron G. Bart, Matt L. Harlow, Patrick R. Arsenault, Nico R. Cantone, Rebecca L. Casaubon, Hari B. Kamadurai, Aravind Prasad Medikonda, Duncan E. Nunes, Tim J. Wigle, Maolin Yu, Aleksandra Zagulyaeva, Christine Zarate, Lauren Highfield, Nobuyuki Kondo, Aaron N. Hata, Kenneth Ngo, Jisu Lee, Prafulla C. Gokhale, Kathleen I. Seyb, Patrick Trojer, Vito J. Palombella

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Source: LUNGevity Foundation · x.com