KRAS / RAS targeting: from platform to Phase 3
The floor also showed dual ON/OFF (VS-7375) and RM-055, built for amplification and daraxonrasib-resistant models.
The floor rewrote the question from “how long can G12C monotherapy last” to “who first makes first-line pancreatic cancer a standard.” daraxonrasib’s Phase 3 is still the only RAS-inhibitor overall-survival win.
I've learned so much about the regulatory side of drug development through this fellowship, especially with daraxonrasib currently under evaluation for accelarated approval. Thank you to @AACR & @US_FDA for hosting me at #AACR26! Looking foward to meeting again soon at the FDA.
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