doi.org· Gut microbes·· 2 days agoPickScore74
Intratumoral Fusobacterium nucleatum promotes ferroptosis resistance and a disulfide-stress-associated vulnerability under glucose restriction
In brief
Intratumoral Fusobacterium nucleatum (Fn) infection raises SLC7A11 expression and attenuates Era- and RSL3-induced ferroptosis, leaving cells relatively resistant to ferroptosis when glucose is abundant. H2S produced during Fn infection contributes to SLC7A11 upregulation and the downstream GSH/GPX4 axis response, alongside reduced lipid-peroxide and Fe2+ accumulation, ACSL4 downregulation, and FTH1 upregulation.
Why it matters
Contrasting glucose-replete and glucose-restricted conditions separates ferroptosis resistance from disulfide-stress vulnerability in Fn-infected cells, providing experimental grounds for combined interventions.
Source: doi.org · doi.org