Safety/efficacy of JNJ-6143, a first-in-class RIPTAC in heavily pre-Rxed pts with mCRPC @BGarmezy @urotoday #ESMO26

🚨Ph 1 n=105; RP2D: 50 mg
🚨At 50 mg:
- <60% any-grade TRAEs
- 77% PSA50; 48% PSA90
- High PSA RR irrespective of HR molecular features
- 69% ORR