Molecular Cell· Agnieszka Obarska-Kosinska, Ying Zhu, Katharina Geißler, Remus R.E. Rosenkranz, Nanako Yokoyama, Jan Philipp Kreysing, Huaipeng Xing, Desislava Glushkova, Marta Anna Kubańska, Stefanie Böhm, Hans-Georg Kräusslich, Beata Turoňová, Fan Liu, Martin Beck·· 1 day agoPickScore70
How the TREX-2 complex associates with the nuclear pore
In brief
Agnieszka Obarska-Kosinska and colleagues built an extended model of the human nuclear pore, adding five nucleoporins and resolving how the nuclear basket and the TREX-2 complex attach to the nuclear ring. Combining cryo-electron tomography, AI-assisted modeling, and crosslinking mass spectrometry, the work reveals the spatial organization of the pore relevant to mRNP export.
Why it matters
Adds five nucleoporins and resolves how TREX-2 links to the nuclear ring, providing a structural reference for mRNP export.
Source: Molecular Cell · cell.com