KRAS / RAS targeting: from platform to Phase 3
The floor also showed dual ON/OFF (VS-7375) and RM-055, built for amplification and daraxonrasib-resistant models.
The floor rewrote the question from “how long can G12C monotherapy last” to “who first makes first-line pancreatic cancer a standard.” daraxonrasib’s Phase 3 is still the only RAS-inhibitor overall-survival win.
Daraxonrasib (RMC-6236), a promising pan-RAS inhibitor from @RevMedicines, vs docetaxel trial in KRAS mutant NSCLC is ongoing.
Great to see Dr. @FSkoulidis at #AACR26 https://t.co/I5NYYTglZr
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