KRAS / RAS targeting: from platform to Phase 3
The floor also showed dual ON/OFF (VS-7375) and RM-055, built for amplification and daraxonrasib-resistant models.
The floor rewrote the question from “how long can G12C monotherapy last” to “who first makes first-line pancreatic cancer a standard.” daraxonrasib’s Phase 3 is still the only RAS-inhibitor overall-survival win.
Pancreatic cancer research at #AACR26: Dr. Brian Wolpin of @DanaFarber_Hale presents encouraging data on safety and efficacy from a small study combining the RAS inhibitor daraxonrasib with chemotherapy in patients with advanced #PancreaticCancer. @danafarber
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