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Prof. Dr. Ahmet Dirican· @dr_dirican · X·· 3 hours agoScore70

durvalumab

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ESMO 2026 | Does immune activation translate into tumor eradication?

After two doses of durvalumab in stage I TNBC:

• pCR: 1.4%
• sTILs: 10% → 22%
• PD-L1 CPS: 10 → 20

Robust immune activation, but minimal pathological response.

#ESMO26 #TNBC #Immunotherapy
@myESMO

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Conference abstracts
2879ROmatched by Rapid oral 1: Gastrointestinal tumour, upper digestive

Durvalumab plus definitive chemoradiotherapy versus definitive chemoradiotherapy in patients with locally advanced esophagus carcinoma: ARION PRODIGE 67 randomized phase 2 trial

https://esmocongress.esmo.org
4737ROmatched by Rapid oral 1: Genitourinary tumours, renal and urothelial

Durvalumab (D) in Combination With BCG Induction and Maintenance (I+M) for BCG-Naïve, High-Risk Non-Muscle-Invasive Bladder Cancer (NMIBC): Early Recurrence and Cystectomy-Free Survival in Patients (pts) With Papillary Only Tumours From POT

https://esmocongress.esmo.org
LBA2matched by Presidential Symposium I

Perioperative durvalumab with or without tremelimumab plus neoadjuvant enfortumab vedotin in muscle-invasive bladder cancer: Results from the phase 3 VOLGA trial

https://esmocongress.esmo.org
LBA26matched by Proffered paper 2: Breast cancer, early and advanced stage

Short-term preoperative durvalumab for stage I TNBC: First results from the phase II UNLOCK 14 - POP-DURVA trial

https://esmocongress.esmo.org
LBA3matched by Presidential Symposium I

Tarlatamab plus durvalumab (durva) vs durva as 1L maintenance (1LM) therapy following durva, platinum, and etoposide (1L durva + EP) in extensive-stage small cell lung cancer (ES-SCLC): Primary analysis of the phase 3 DeLLphi-305 trial

https://esmocongress.esmo.org
LBA37matched by Proffered paper: Gynaecological cancers

Durvalumab (D) plus carboplatin/paclitaxel (CP) followed by D with or without olaparib (O) in advanced/recurrent endometrial cancer (a/rEC): Interim overall survival (OS) and safety from the randomised phase 3 DUO-E/GOG-3041/ENGOT-EN10 stud

https://esmocongress.esmo.org

Source: Prof. Dr. Ahmet Dirican · x.com

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