Exciting intracranial activity with Dato-DXd in mTNBC + brain mets (TROPION-Breast02 subgroup, #ESMO26).
CNS PFS 9.5 vs 2.6 mo (HR 0.27)
icORR 62.5% vs 37.5% (measurable)
OS signal in untreated BMs (HR 0.35)

Preferred Trop2 ADC for CNS disease? Exploratory (small n) but clear signal. #bcsm