KRAS / RAS targeting: from platform to Phase 3
The floor also showed dual ON/OFF (VS-7375) and RM-055, built for amplification and daraxonrasib-resistant models.
The floor rewrote the question from “how long can G12C monotherapy last” to “who first makes first-line pancreatic cancer a standard.” daraxonrasib’s Phase 3 is still the only RAS-inhibitor overall-survival win.
Waiting for two abstracts to be presented the whole @AACR #AACR26, this is one of them
Just presented, #Daraxonrasib in #mKRAS #PDAC by @EileenMOReilly
#Monotherapy in the #FirstLine
38 pts
ORR 47%
Time on tto 7.7m
PFS immature
Ongoing Phase III 303 (Dara vs GemNab+/-Dara) https://t.co/wUGkbo9rRk
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