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Vilma P. Barcia MD, PhD, MSc· @DrVilmaPBarcia · X·· 2 days agoScore70

HER2

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🚨 #ESMO26 | Phase II TQB2102-II-04 in 1L HER2+ gastric/GEJ cancer.
TQB2102 (HER2 ADC) + benmelstobart + capecitabine:
🔹 ORR 84.2% (95.8% at 6 mg/kg)
🔹 DCR 100%
🔹 mPFS 11.0 months
Promising activity and manageable safety. Phase III planned.
#GIOnc @OncoAlert @myESMO

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Conference abstracts
1766ROmatched by Rapid oral 1: Breast cancer, advanced stage

Health-related quality of life from HER2CLIMB-05: A phase 3 study of tucatinib versus placebo in combination with trastuzumab and pertuzumab as 1L maintenance therapy for HER2+ mBC

https://esmocongress.esmo.org
1780Pmatched by HER2+ breast cancer

Safety, social costs and quality of life (QOL) in HER2-positive (HER2+) breast cancer (BC) patients (pts) treated with pertuzumab + trastuzumab fixed-dose combination subcutaneous (PT FDC SC): The PERTURB study

https://esmocongress.esmo.org
1795TIPmatched by HER2+ breast cancer

A global, interventional, open-label trial of trastuzumab deruxtecan (T-DXd)–based therapy in first-line HER2-positive metastatic breast cancer: DESTINY-Breast Guide

https://esmocongress.esmo.org
1842Omatched by Proffered paper 2: Breast cancer, early and advanced stage

Efficacy and safety of atirmociclib (ATI) + fulvestrant (FUL) in patients (pts) with HR+/HER2– advanced/metastatic breast cancer (mBC) who progressed on prior CDK4/6 inhibitor (CDK4/6i) in a randomized phase 2 study (FOURLIGHT-1)

https://esmocongress.esmo.org
1844Pmatched by HR+ breast cancer

Gene-expression profiling of HR+/HER2- breast cancers arising in germline BRCA1/2 mutation carriers

https://esmocongress.esmo.org

Source: Vilma P. Barcia MD, PhD, MSc · x.com

CBACBA Frontier Insights (CFI)Chinese Biopharmaceutical Association (CBA)www.cba-usa.org