Molecular Cell· Helen E. Grimsley, Katherine Courtemanche, Shane Cox, Anthony Calder, Niamh McDermott, Xin Pei, Aman Sharma, Jackson Bright, Nadeem Riaz, Jeremy Setton, Mehmet Orman, Simon N. Powell·· 18 hours agoPickScore68
The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer
In brief
Research shows the 9-1-1 complex protects BRCA2-deficient cancer cells from lethal ssDNA gap accumulation by suppressing PRIMPOL-dependent gap formation and promoting POLζ-mediated filling. The mechanism also includes restraining EXO1 degradation and reveals an ATR-independent role in post-replicative repair. The study establishes gap length as a key determinant of repair pathway choice.
Why it matters
The work reveals how the 9-1-1 complex protects BRCA2-deficient cancer cells and identifies gap length as a key determinant of post-replicative repair pathway choice.
