N Engl J Med·· 23 hours agoPickScore85
Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea.
In brief
Two phase 3 trials randomized 243 and 448 patients, respectively. Once-weekly retatrutide significantly reduced AHI compared with placebo at 80 weeks in adults with obesity or overweight and moderate-to-severe obstructive sleep apnea.
Why it matters
Two placebo-controlled trials enrolled patients without and with type 2 diabetes, with AHI effect sizes and 95% CIs available for comparison.
Source: N Engl J Med · doi.org